Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease
Identifieur interne : 000C62 ( Main/Corpus ); précédent : 000C61; suivant : 000C63Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease
Auteurs : Giuseppe Nicoletti ; Caterina Tonon ; Raffaele Lodi ; Francesca Condino ; David Manners ; Emil Malucelli ; Maurizio Morelli ; Fabiana Novellino ; Sandra Paglionico ; Pierluigi Lanza ; Demetrio Messina ; Paolo Barone ; Letterio Morgante ; Mario Zappia ; Bruno Barbiroli ; Aldo QuattroneSource :
- Movement Disorders [ 0885-3185 ] ; 2008-12-15.
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Abstract
The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA‐P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we assessed the SCP apparent diffusion coefficient (ADC) values in patients with PSP, PD, and MSA‐P in order to evaluate its differential diagnostic value in vivo. Twenty‐eight patients with PSP (14 with possible‐PSP and 14 with probable‐PSP), 15 PD, 15 MSA‐P, and 16 healthy subjects were studied by using diffusion weighted imaging (DWI). ADC was calculated in regions of interest defined in the left and right SCP by two clinically blinded operators. Intrarater (r = 0.98, P < 0.001) and interrater reliability (r = 0.97; P < 0.001) for SCP measurements were high. Patients with PSP had higher SCP rADC values (median 0.98 × 10−3mm2/s) than patients with PD (median 0.79 × 10−3 mm2/s, P < 0.001), MSA‐P (median 0.79 × 10−3 mm2/s, P < 0.001), and healthy controls (median 0.80 × 10−3 mm2/s, P < 0.001). DWI discriminated patients with PSP from PD and healthy subjects on the basis of SCP rADC individual values (100% sensitivity and specificity) and from patients with MSA‐P (96.4% sensitivity and 93.3% specificity). The higher values of rADC in SCP of patients with PSP correspond with the in vivo microstructural feature of atrophy detected postmortem and provide an additional support for early discrimination between PSP and other neurodegenerative parkinsonisms. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22279
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Campanacci”, Università di Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.22279</idno><idno type="url">https://api.istex.fr/document/B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000C62</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease</title><author><name sortKey="Nicoletti, Giuseppe" sort="Nicoletti, Giuseppe" uniqKey="Nicoletti G" first="Giuseppe" last="Nicoletti">Giuseppe Nicoletti</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name><affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name><affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Condino, Francesca" sort="Condino, Francesca" uniqKey="Condino F" first="Francesca" last="Condino">Francesca Condino</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name><affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name><affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Morelli, Maurizio" sort="Morelli, Maurizio" uniqKey="Morelli M" first="Maurizio" last="Morelli">Maurizio Morelli</name><affiliation><mods:affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Novellino, Fabiana" sort="Novellino, Fabiana" uniqKey="Novellino F" first="Fabiana" last="Novellino">Fabiana Novellino</name><affiliation><mods:affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Paglionico, Sandra" sort="Paglionico, Sandra" uniqKey="Paglionico S" first="Sandra" last="Paglionico">Sandra Paglionico</name><affiliation><mods:affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Lanza, Pierluigi" sort="Lanza, Pierluigi" uniqKey="Lanza P" first="Pierluigi" last="Lanza">Pierluigi Lanza</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Messina, Demetrio" sort="Messina, Demetrio" uniqKey="Messina D" first="Demetrio" last="Messina">Demetrio Messina</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Department of Neurological Sciences, University Federico II, Napoli, Italy</mods:affiliation></affiliation></author><author><name sortKey="Morgante, Letterio" sort="Morgante, Letterio" uniqKey="Morgante L" first="Letterio" last="Morgante">Letterio Morgante</name><affiliation><mods:affiliation>Department of Neuroscience, Psychiatry and Anestesiology, Policlinico Universitario, University of Messina, Messina, Italy</mods:affiliation></affiliation></author><author><name sortKey="Zappia, Mario" sort="Zappia, Mario" uniqKey="Zappia M" first="Mario" last="Zappia">Mario Zappia</name><affiliation><mods:affiliation>Dipartimento di Neuroscienze, Clinica Neurologica I, Università di Catania, Catania, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name><affiliation><mods:affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</mods:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-12-15">2008-12-15</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2370">2370</biblScope><biblScope unit="page" to="2376">2376</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38</idno><idno type="DOI">10.1002/mds.22279</idno><idno type="ArticleID">MDS22279</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DWI</term><term>Parkinson's disease</term><term>multiple system atrophy</term><term>neurodegenerative disorders</term><term>progressive supranuclear palsy</term><term>superior cerebellar peduncle</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA‐P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we assessed the SCP apparent diffusion coefficient (ADC) values in patients with PSP, PD, and MSA‐P in order to evaluate its differential diagnostic value in vivo. Twenty‐eight patients with PSP (14 with possible‐PSP and 14 with probable‐PSP), 15 PD, 15 MSA‐P, and 16 healthy subjects were studied by using diffusion weighted imaging (DWI). ADC was calculated in regions of interest defined in the left and right SCP by two clinically blinded operators. Intrarater (r = 0.98, P < 0.001) and interrater reliability (r = 0.97; P < 0.001) for SCP measurements were high. Patients with PSP had higher SCP rADC values (median 0.98 × 10−3mm2/s) than patients with PD (median 0.79 × 10−3 mm2/s, P < 0.001), MSA‐P (median 0.79 × 10−3 mm2/s, P < 0.001), and healthy controls (median 0.80 × 10−3 mm2/s, P < 0.001). DWI discriminated patients with PSP from PD and healthy subjects on the basis of SCP rADC individual values (100% sensitivity and specificity) and from patients with MSA‐P (96.4% sensitivity and 93.3% specificity). The higher values of rADC in SCP of patients with PSP correspond with the in vivo microstructural feature of atrophy detected postmortem and provide an additional support for early discrimination between PSP and other neurodegenerative parkinsonisms. © 2008 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Giuseppe Nicoletti MD</name><affiliations><json:string>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</json:string><json:string>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Caterina Tonon MD</name><affiliations><json:string>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Raffaele Lodi MD</name><affiliations><json:string>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Francesca Condino PhD</name><affiliations><json:string>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</json:string></affiliations></json:item><json:item><name>David Manners DPhil</name><affiliations><json:string>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Emil Malucelli PhD</name><affiliations><json:string>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Maurizio Morelli MD</name><affiliations><json:string>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Fabiana Novellino MD</name><affiliations><json:string>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Sandra Paglionico MD</name><affiliations><json:string>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Pierluigi Lanza MD</name><affiliations><json:string>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</json:string></affiliations></json:item><json:item><name>Demetrio Messina MD</name><affiliations><json:string>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</json:string><json:string>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</json:string></affiliations></json:item><json:item><name>Paolo Barone MD</name><affiliations><json:string>Department of Neurological Sciences, University Federico II, Napoli, Italy</json:string></affiliations></json:item><json:item><name>Letterio Morgante MD</name><affiliations><json:string>Department of Neuroscience, Psychiatry and Anestesiology, Policlinico Universitario, University of Messina, Messina, Italy</json:string></affiliations></json:item><json:item><name>Mario Zappia MD</name><affiliations><json:string>Dipartimento di Neuroscienze, Clinica Neurologica I, Università di Catania, Catania, Italy</json:string></affiliations></json:item><json:item><name>Bruno Barbiroli MD</name><affiliations><json:string>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</json:string></affiliations></json:item><json:item><name>Aldo Quattrone MD</name><affiliations><json:string>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</json:string><json:string>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>progressive supranuclear palsy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>superior cerebellar peduncle</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>DWI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>neurodegenerative disorders</value></json:item></subject><articleId><json:string>MDS22279</json:string></articleId><language><json:string>eng</json:string></language><abstract>The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA‐P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we assessed the SCP apparent diffusion coefficient (ADC) values in patients with PSP, PD, and MSA‐P in order to evaluate its differential diagnostic value in vivo. Twenty‐eight patients with PSP (14 with possible‐PSP and 14 with probable‐PSP), 15 PD, 15 MSA‐P, and 16 healthy subjects were studied by using diffusion weighted imaging (DWI). ADC was calculated in regions of interest defined in the left and right SCP by two clinically blinded operators. Intrarater (r = 0.98, P > 0.001) and interrater reliability (r = 0.97; P > 0.001) for SCP measurements were high. Patients with PSP had higher SCP rADC values (median 0.98 × 10−3mm2/s) than patients with PD (median 0.79 × 10−3 mm2/s, P > 0.001), MSA‐P (median 0.79 × 10−3 mm2/s, P > 0.001), and healthy controls (median 0.80 × 10−3 mm2/s, P > 0.001). DWI discriminated patients with PSP from PD and healthy subjects on the basis of SCP rADC individual values (100% sensitivity and specificity) and from patients with MSA‐P (96.4% sensitivity and 93.3% specificity). The higher values of rADC in SCP of patients with PSP correspond with the in vivo microstructural feature of atrophy detected postmortem and provide an additional support for early discrimination between PSP and other neurodegenerative parkinsonisms. © 2008 Movement Disorder Society</abstract><qualityIndicators><score>7.482</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1792</abstractCharCount><pdfWordCount>4482</pdfWordCount><pdfCharCount>27901</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>276</abstractWordCount></qualityIndicators><title>Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>23</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>7</total><last>2376</last><first>2370</first></pages><issn><json:string>0885-3185</json:string></issn><issue>16</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1002/mds.22279</json:string></doi><id>B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2008</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None reported.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease</title><author><persName><forename type="first">Giuseppe</forename><surname>Nicoletti</surname></persName><roleName type="degree">MD</roleName><affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</affiliation><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation></author><author><persName><forename type="first">Caterina</forename><surname>Tonon</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Raffaele</forename><surname>Lodi</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Francesca</forename><surname>Condino</surname></persName><roleName type="degree">PhD</roleName><affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</affiliation></author><author><persName><forename type="first">David</forename><surname>Manners</surname></persName><roleName type="degree">DPhil</roleName><affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Emil</forename><surname>Malucelli</surname></persName><roleName type="degree">PhD</roleName><affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Maurizio</forename><surname>Morelli</surname></persName><roleName type="degree">MD</roleName><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation></author><author><persName><forename type="first">Fabiana</forename><surname>Novellino</surname></persName><roleName type="degree">MD</roleName><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation></author><author><persName><forename type="first">Sandra</forename><surname>Paglionico</surname></persName><roleName type="degree">MD</roleName><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation></author><author><persName><forename type="first">Pierluigi</forename><surname>Lanza</surname></persName><roleName type="degree">MD</roleName><affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</affiliation></author><author><persName><forename type="first">Demetrio</forename><surname>Messina</surname></persName><roleName type="degree">MD</roleName><affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</affiliation><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation></author><author><persName><forename type="first">Paolo</forename><surname>Barone</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University Federico II, Napoli, Italy</affiliation></author><author><persName><forename type="first">Letterio</forename><surname>Morgante</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neuroscience, Psychiatry and Anestesiology, Policlinico Universitario, University of Messina, Messina, Italy</affiliation></author><author><persName><forename type="first">Mario</forename><surname>Zappia</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Neuroscienze, Clinica Neurologica I, Università di Catania, Catania, Italy</affiliation></author><author><persName><forename type="first">Bruno</forename><surname>Barbiroli</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</affiliation></author><author><persName><forename type="first">Aldo</forename><surname>Quattrone</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Clinica Neurologica, Policlinico Universitario “Mater Domini”, Campus Universitario Germaneto, Viale Europa, 88100 Catanzaro, Italy</p></note><affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</affiliation><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-12-15"></date><biblScope unit="volume">23</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2370">2370</biblScope><biblScope unit="page" to="2376">2376</biblScope></imprint></monogr><idno type="istex">B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38</idno><idno type="DOI">10.1002/mds.22279</idno><idno type="ArticleID">MDS22279</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA‐P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we assessed the SCP apparent diffusion coefficient (ADC) values in patients with PSP, PD, and MSA‐P in order to evaluate its differential diagnostic value in vivo. Twenty‐eight patients with PSP (14 with possible‐PSP and 14 with probable‐PSP), 15 PD, 15 MSA‐P, and 16 healthy subjects were studied by using diffusion weighted imaging (DWI). ADC was calculated in regions of interest defined in the left and right SCP by two clinically blinded operators. Intrarater (r = 0.98, P < 0.001) and interrater reliability (r = 0.97; P < 0.001) for SCP measurements were high. Patients with PSP had higher SCP rADC values (median 0.98 × 10−3mm2/s) than patients with PD (median 0.79 × 10−3 mm2/s, P < 0.001), MSA‐P (median 0.79 × 10−3 mm2/s, P < 0.001), and healthy controls (median 0.80 × 10−3 mm2/s, P < 0.001). DWI discriminated patients with PSP from PD and healthy subjects on the basis of SCP rADC individual values (100% sensitivity and specificity) and from patients with MSA‐P (96.4% sensitivity and 93.3% specificity). The higher values of rADC in SCP of patients with PSP correspond with the in vivo microstructural feature of atrophy detected postmortem and provide an additional support for early discrimination between PSP and other neurodegenerative parkinsonisms. © 2008 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>progressive supranuclear palsy</term></item><item><term>Parkinson's disease</term></item><item><term>multiple system atrophy</term></item><item><term>superior cerebellar peduncle</term></item><item><term>DWI</term></item><item><term>neurodegenerative disorders</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-10-11">Received</change><change when="2008-07-20">Registration</change><change when="2008-12-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. 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href="file:MDS.MDS22279.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="28"></count><count type="wordTotal" number="5316"></count></countGroup><titleGroup><title type="main" xml:lang="en">Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease<link href="#fn10"></link></title><title type="short" xml:lang="en">DWI Differentiates PSP from PD and MSA‐P</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Giuseppe</givenNames><familyName>Nicoletti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Caterina</givenNames><familyName>Tonon</familyName><degrees>MD</degrees></personName></creator><creator 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affiliationRef="#af5"><personName><givenNames>Letterio</givenNames><familyName>Morgante</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Mario</givenNames><familyName>Zappia</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au15" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Bruno</givenNames><familyName>Barbiroli</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au16" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Aldo</givenNames><familyName>Quattrone</familyName><degrees>MD</degrees></personName><contactDetails><email>a.quattrone@isn.cnr.it</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurological Sciences, University Federico II, Napoli, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neuroscience, Psychiatry and Anestesiology, Policlinico Universitario, University of Messina, Messina, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Neuroscienze, Clinica Neurologica I, Università di Catania, Catania, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">progressive supranuclear palsy</keyword><keyword xml:id="kwd2">Parkinson's disease</keyword><keyword xml:id="kwd3">multiple system atrophy</keyword><keyword xml:id="kwd4">superior cerebellar peduncle</keyword><keyword xml:id="kwd5">DWI</keyword><keyword xml:id="kwd6">neurodegenerative disorders</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA‐P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we assessed the SCP apparent diffusion coefficient (ADC) values in patients with PSP, PD, and MSA‐P in order to evaluate its differential diagnostic value <i>in vivo</i>. Twenty‐eight patients with PSP (14 with possible‐PSP and 14 with probable‐PSP), 15 PD, 15 MSA‐P, and 16 healthy subjects were studied by using diffusion weighted imaging (DWI). ADC was calculated in regions of interest defined in the left and right SCP by two clinically blinded operators. Intrarater (r = 0.98, <i>P</i> < 0.001) and interrater reliability (r = 0.97; <i>P</i> < 0.001) for SCP measurements were high. Patients with PSP had higher SCP rADC values (median 0.98 × 10<sup>−3</sup>mm<sup>2</sup>/s) than patients with PD (median 0.79 × 10<sup>−3</sup> mm<sup>2</sup>/s, <i>P</i> < 0.001), MSA‐P (median 0.79 × 10<sup>−3</sup> mm<sup>2</sup>/s, <i>P</i> < 0.001), and healthy controls (median 0.80 × 10<sup>−3</sup> mm<sup>2</sup>/s, <i>P</i> < 0.001). DWI discriminated patients with PSP from PD and healthy subjects on the basis of SCP rADC individual values (100% sensitivity and specificity) and from patients with MSA‐P (96.4% sensitivity and 93.3% specificity). The higher values of rADC in SCP of patients with PSP correspond with the <i>in vivo</i> microstructural feature of atrophy detected postmortem and provide an additional support for early discrimination between PSP and other neurodegenerative parkinsonisms. © 2008 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn10"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>DWI Differentiates PSP from PD and MSA‐P</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Giuseppe</namePart><namePart type="family">Nicoletti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</affiliation><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Caterina</namePart><namePart type="family">Tonon</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Raffaele</namePart><namePart type="family">Lodi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesca</namePart><namePart type="family">Condino</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David</namePart><namePart type="family">Manners</namePart><namePart type="termsOfAddress">DPhil</namePart><affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Emil</namePart><namePart type="family">Malucelli</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maurizio</namePart><namePart type="family">Morelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fabiana</namePart><namePart type="family">Novellino</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sandra</namePart><namePart type="family">Paglionico</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierluigi</namePart><namePart type="family">Lanza</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Demetrio</namePart><namePart type="family">Messina</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</affiliation><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Barone</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University Federico II, Napoli, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Letterio</namePart><namePart type="family">Morgante</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuroscience, Psychiatry and Anestesiology, Policlinico Universitario, University of Messina, Messina, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mario</namePart><namePart type="family">Zappia</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Neuroscienze, Clinica Neurologica I, Università di Catania, Catania, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bruno</namePart><namePart type="family">Barbiroli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Medicina Clinica e Biotecnologia Applicata “D. Campanacci”, Università di Bologna, Bologna, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aldo</namePart><namePart type="family">Quattrone</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy</affiliation><affiliation>Institute of Neurology, Department of Medical Sciences, University Magna Graecia, Catanzaro, Italy</affiliation><description>Correspondence: Clinica Neurologica, Policlinico Universitario “Mater Domini”, Campus Universitario Germaneto, Viale Europa, 88100 Catanzaro, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2008-12-15</dateIssued><dateCaptured encoding="w3cdtf">2007-10-11</dateCaptured><dateValid encoding="w3cdtf">2008-07-20</dateValid><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">3</extent><extent unit="references">28</extent><extent unit="words">5316</extent></physicalDescription><abstract lang="en">The early diagnosis of progressive supranuclear palsy (PSP) may be challenging, because of clinical overlapping features with Parkinson's disease (PD) and other parkinsonian syndromes such as the Parkinsonian variant of multiple system atrophy (MSA‐P). Conventional MRI can help in differentiating parkinsonian disorders but its diagnostic accuracy is still unsatisfactory. On the basis of the pathological demonstration of superior cerebellar peduncle (SCP) atrophy in patients with PSP, we assessed the SCP apparent diffusion coefficient (ADC) values in patients with PSP, PD, and MSA‐P in order to evaluate its differential diagnostic value in vivo. Twenty‐eight patients with PSP (14 with possible‐PSP and 14 with probable‐PSP), 15 PD, 15 MSA‐P, and 16 healthy subjects were studied by using diffusion weighted imaging (DWI). ADC was calculated in regions of interest defined in the left and right SCP by two clinically blinded operators. Intrarater (r = 0.98, P < 0.001) and interrater reliability (r = 0.97; P < 0.001) for SCP measurements were high. Patients with PSP had higher SCP rADC values (median 0.98 × 10−3mm2/s) than patients with PD (median 0.79 × 10−3 mm2/s, P < 0.001), MSA‐P (median 0.79 × 10−3 mm2/s, P < 0.001), and healthy controls (median 0.80 × 10−3 mm2/s, P < 0.001). DWI discriminated patients with PSP from PD and healthy subjects on the basis of SCP rADC individual values (100% sensitivity and specificity) and from patients with MSA‐P (96.4% sensitivity and 93.3% specificity). The higher values of rADC in SCP of patients with PSP correspond with the in vivo microstructural feature of atrophy detected postmortem and provide an additional support for early discrimination between PSP and other neurodegenerative parkinsonisms. © 2008 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><subject lang="en"><genre>Keywords</genre><topic>progressive supranuclear palsy</topic><topic>Parkinson's disease</topic><topic>multiple system atrophy</topic><topic>superior cerebellar peduncle</topic><topic>DWI</topic><topic>neurodegenerative disorders</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>16</number></detail><extent unit="pages"><start>2370</start><end>2376</end><total>7</total></extent></part></relatedItem><identifier type="istex">B7F9CB6F8450FDFEE0DF2BF7EC8D30A017F93B38</identifier><identifier type="DOI">10.1002/mds.22279</identifier><identifier type="ArticleID">MDS22279</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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